Abstract
The application of a novel solid-phase synthesis of 2,3-disubstituted indoles utilizing a carbamate indole linker is described resulting in the identification of the novel, high-affinity, selective h5-HT2A antagonist 19.
MeSH terms
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Binding, Competitive
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Combinatorial Chemistry Techniques
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Humans
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Indoles / chemical synthesis*
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Indoles / pharmacology*
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Receptors, Dopamine D2 / metabolism
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Receptors, Serotonin / metabolism
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Serotonin Antagonists / chemical synthesis*
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Serotonin Antagonists / pharmacology
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Tryptamines / chemistry
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Tryptamines / pharmacology
Substances
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Indoles
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Receptors, Dopamine D2
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Receptors, Serotonin
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Serotonin Antagonists
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Tryptamines